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Beilstein J. Org. Chem. 2015, 11, 2631–2640, doi:10.3762/bjoc.11.282
Graphical Abstract
Scheme 1: Double reductive amination on aldehyde 2 allowed the synthesis of trihydroxypiperidines, among whic...
Scheme 2: Synthesis of key azide intermediate 4 through the double reductive amination strategy from “masked”...
Scheme 3: Tetravalent and nonavalent alkyne scaffolds.
Scheme 4: Synthesis of the tetravalent adduct 7 by CuAAC reaction and its deprotection/purification process t...
Scheme 5: Synthesis of nonavalent adduct 11 by CuAAC reaction and its deprotection.
Scheme 6: Synthesis of the monovalent iminosugar 15 by CuAAC reaction and subsequent deprotection of the hydr...
Beilstein J. Org. Chem. 2012, 8, 514–521, doi:10.3762/bjoc.8.58
Figure 1: Structure of trehalose (1), validoxylamine A (2), 1-thiatrehazolin (3), trehalostatin (4), casuarin...
Figure 2: Structure of nojirimycin-based (7, 8) and pyrrolidine-based (9) leads.
Figure 3: Structures of potential inhibitors 10–21.
Scheme 1: Synthesis of nojirimycin-based inhibitors 10,12 and 13. Reagents and conditions: (a) H2, Pd/C, NH4O...
Scheme 2: Synthesis of pyrrolidine derivatives 14, 16, 17 and 19. Reagents and conditions: (a) H2, Pd(OH)2/C,...
Scheme 3: Synthesis of pyrrolidines 20 and 21. Reagents and conditions: (a) H2, Pd/C, MeOH, HCl; (b) octanal,...
Figure 4: Histogram of the inhibitory activity of compounds 7–10, 12–14, 16 and 20. Derivatives 10, 14 and 16...
Beilstein J. Org. Chem. 2007, 3, No. 44, doi:10.1186/1860-5397-3-44
Scheme 1: Synthesis of symmetrically α,α'-disubstituted hydroxylamines 1.
Scheme 2: Synthesis of unsymmetrically α,α'-disubstituted hydroxylamines 3.
Scheme 3: Synthesis of piperidines 15–16 and azepine 17. Reagents and conditions: a) Ac2O, THF, 1 h, rt for 8...
Scheme 4: Synthesis of indolizidines 21–22 and pyrroloazepine 23. Reaction conditions: a) Tf2O, Py, rt, 2 h; ...